5-MTHF folate is the most abundant folate present in the human body. It is found naturally in food, but is more easily absorbed from food supplements. MTHF folate is the most bioavailable folate found in food supplements. It can be used immediately by your body and does not need to be converted by the enzyme methylenetetrahydrofolate reductase (MTHFR).
Up to 25% of the population has a variant in the MTHFR gene (MTHFR 677TT) which significantly impairs its ability to metabolise folic acid. Research is still preliminary, but people with the MTHFR 677TT variant are likely to benefit from MTHF folate supplementation rather than folic acid supplementation.
